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AstraZeneca receives positive Phase III trial results from Enhertu study
Drugmaker AstraZeneca said on Tuesday that it had received "positive high-level results" from a Phase III trial on its Enhertu candidate, developed in conjunction with Daiichi Sankyo.

US close: Dow reverses Monday's losses on trade war optimism
Major indices closed sharply higher on Tuesday as traders grew optimistic that US-China trade tensions could ease soon.

US Treasury Secretary expects trade war with China to de-escalate
The head of America's Treasury believes that the trade war with China will de-escalate.

Russia offers to halt invasion at current frontline
The Russian president has offered to stop the invasion of Ukraine at the point where the frontline currently stands.

Europe close: Late rally pushes Stoxx 600 modestly higher
Markets across Europe managed to push higher by Tuesday's close as traders returned to their desks following the four-day Easter weekend, with sentiment helped by a strong rebound on Wall Street.

Director dealings: Safestore CEO raises stake
Safestore revealed on Tuesday that chief executive Frederic Vecchioli had acquired 51,000 ordinary shares in the FTSE 250-listed self-storage firm.

Wednesday preview: Iran, Ukraine, Global PMIs in focus
Financial markets' focus in the middle of the week will be on geopolitics, with top level officials from the US, Ukraine and Europe set to meet in London.

London close: Stocks mixed, gold jumps as volatility continues
London stocks ended Tuesday in mixed territory, amid subdued trading in the absence of significant economic data, leaving investors without a clear catalyst following a sharp sell-off on Wall Street on Easter Monday.

Richmond Fed's manufacturing index plummets in April
The Richmond Federal Reserve's manufacturing index plummeted to -13 in April, down from March's -4 reading and far worse than analysts' estimates of -6.

US open: Dow Jones claws back some of yesterday's heavy losses
Major indices reclaimed some of yesterday's heavy losses early on Tuesday as markets remain volatile following the announcement of Donald Trump's "reciprocal" tariffs earlier this month.

FTSE 100 movers: Bunzl rebounds after profit warning, DCC falls
Bunzl, Sainsbury's, Fresnillo and Admiral were among Tuesday's best performers on the top-tier index, while CRH, Flutter and DCC were registering losses.

AOTI gets TWO2 included on NHS Supply Chain framework
AOTI announced on Tuesday that it has secured inclusion of its Topical Wound Oxygen (TWO2) therapy in the NHS Supply Chain framework agreement for advanced wound care, effective from 1 September.

Admiral sells US motor division to JC Flowers
Insurance group Admiral is to sell its US motor insurance unit to American private equity investment firm JC Flowers & Co for an undisclosed amount.

Berenberg names Admiral among top picks in European insurance
Berenberg analysts have named UK-listed motor insurer Admiral among their top picks in the European insurance sector.
Europe midday: Stoxx extends losses as Trump/Powell spat spooks investors
European shares extended losses on Tuesday and gold hit $3,500 for the first time amid concerns over the US Federal Reserve’s independence after attacks on its boss Jerome Powell by President Donald Trump and the lack of progress on tariff negotiations by Washington.

US pre-open: Futures higher following Monday's sell-off
Wall Street futures had major indices reclaiming some of yesterday's losses as markets remain volatile following the announcement of Donald Trump's "reciprocal" tariffs earlier this month.

London midday: Sainsbury's, gold miners lift markets but gains limited
London-listed stocks pushed higher by Tuesday lunchtime, though gains were limited with no major economic data or corporate news to steer sentiment following another heavy sell-off on Wall Street the previous session.

Roche to spend $50bn on US manufacturing, R&D sites
Swiss healthcare giant Roche announced on Tuesday that it is planning to spend $50bn in pharmaceuticals and diagnostics in the US over the next five years.

London open: Stocks off lows, geopolitics and trade in focus
The financial newswire headlines are covered in various iterations of 'sell the US' but stocks in London and over on the Continent have moved off their lows.